The degenerative damage to the cartilage in the large joints, such as the knee, or the hip, can be caused by incorrect structure of the joint, or faulty functioning of the joint’s parts (bones, cartilage and soft tissue). The damage caused by the impact, will be caused principally to the cartilage, but also to the bone, the soft tissue in the joint, and to the muscles that hold it. The erosion itself is caused as a result of the great stress on the surfaces of the joints, together with the preliminary factors, that contribute to the degenerative process.

The risk factors that are known to contribute to be tied to osteoarthritis, are composed of genetic, environmental and lifestyle factors, and include: